Hydroxypropyl beta-cyclodextrin, wanda aka fi sani da (2-hydroxypropyl) -β-cyclodextrin, kwayar halittar hydrogen ce a cikin rukunin 2-, 3-, da 6-hydroxyl na ragowar glucose a cikin β-cyclodextrin (β-CD) wanda aka maye gurbinsa da hydroxypropyl zuwa hydroxypropoxy. HP-β-CD ba wai kawai yana da kyakkyawan tasirin envelope akan mahadi da yawa kamar β-CD ba, har ma yana da fa'idodin narkewar ruwa mai yawa da inganta saurin fitarwa da samuwar ƙwayoyin halitta na magungunan da aka lulluɓe a cikin vivo. Bugu da ƙari, HP-β-CD magani ne mai wadatar magani tare da bayanai mafi yawa na aminci da aka tattara kuma babu wata illa mai illa. Hakanan ana iya amfani da HP-β-CD azaman mai kare furotin da mai daidaita shi.
Hydroxypropyl beta-cyclodextrin fari ne ko fari amorphous ko crystalline foda; Ba shi da wari, ɗan daɗi; Ƙarfin shigar da danshi. Wannan samfurin yana narkewa cikin ruwa cikin sauƙi, yana narkewa cikin methanol, ethanol cikin sauƙi, kusan ba ya narkewa a cikin acetone, trichloromethane.
Narkewarhydroxypropyl-B-cyclodextrina cikin ruwa yana da kyau sosai, kuma matakin maye gurbin 4 zuwa sama za a iya mirgine shi da ruwa a kowane rabo, kuma ana iya narkar da shi a cikin ethanol da methanol 50%. Yana da ɗan hygroscopicity na ɗan lokaci. Amma aikin saman da aikin hemolytic yana da ƙarancin ƙarfi. Ba shi da ƙaiƙayi ga tsoka kuma shine ingantaccen mai haɓaka narkewa da maganin magunguna don allura.
Menene amfani da Hydroxypropyl beta-cyclodextrin?
A fannin abinci da kayan ƙanshi
Hydroxypropyl beta-cyclodextrin na iya inganta kwanciyar hankali da aikin ƙwayoyin abinci mai gina jiki na dogon lokaci, yana rufe ko gyara mummunan wari da ɗanɗanon ƙwayoyin abinci mai gina jiki, da kuma inganta tsarin samarwa da ingancin samfura.
A cikin kayan kwalliya
Ana iya amfani da kayan kwalliyar a matsayin masu daidaita yanayi, masu canza yanayi, masu cire ƙamshi, da sauransu, waɗanda za su iya rage ƙarfin ƙwayoyin halitta a cikin kayan kwalliya a kan kyallen fata da membrane na mucous, ƙara ƙarfin sinadaran da ke aiki, da kuma hana gurɓatawa da kuma gurɓata abubuwan gina jiki. Yana da ɗan hygroscopicity.
A fannin likitanci
Hydroxypropyl beta-cyclodextrinzai iya inganta narkewar ruwa na magungunan da ba sa narkewa, ƙara kwanciyar hankali na magani, inganta samuwar magunguna, ƙara ingancin shirye-shiryen magani ko rage yawan magani, daidaita ko sarrafa saurin sakin magunguna, da rage gubar magani. Ana iya amfani da shi azaman jigilar magunguna ta baki, allurai, tsarin isar da magungunan mucosal (gami da mucosa na hanci, dubura, cornea, da sauransu), tsarin isar da magungunan transdermal, magungunan lipophilic da aka yi niyya, kuma ana iya amfani da shi azaman mai kare furotin da mai daidaita shi.
Lokacin Saƙo: Oktoba-20-2023