Hydroxypropyl beta-cyclodextrin, wanda kuma aka sani da (2-hydroxypropyl) -β-cyclodextrin, shine hydrogen atom a cikin ƙungiyoyin 2-, 3-, da 6-hydroxyl na ragowar glucose a cikin β-cyclodextrin (β-CD) wanda aka maye gurbinsu da hydroxypropyl zuwa hydroxypropoxy.HP-β-CD ba wai kawai yana da kyakkyawan sakamako na ambulaf akan yawancin mahadi kamar β-CD ba, amma har ma yana da fa'idodi na babban solubility na ruwa da haɓaka ƙimar sakin da bioavailability na ƙwayoyin da aka ɓoye a cikin vivo.Bugu da ƙari, HP-β-CD shine kayan haɓakar ƙwayoyi tare da mafi girman bayanan aminci da aka tattara kuma ba tare da lahani mara kyau ba.Hakanan za'a iya amfani da HP-β-CD azaman mai kare furotin da daidaitawa.
Hydroxypropyl beta-cyclodextrin fari ne ko fari amorphous ko crystalline foda;Marasa wari, ɗanɗano mai daɗi;Ƙarfin shigar da danshi.Wannan samfurin yana da sauƙin narkewa a cikin ruwa, sauƙi mai narkewa a cikin methanol, ethanol, kusan marar narkewa a cikin acetone, trichloromethane.
A solubility nahydroxypropyl-B-cyclodextrinA cikin ruwa yana da kyau sosai, kuma matakin maye gurbin na 4 da sama na iya zama micible da ruwa a kowane nau'i, kuma ana iya narkar da shi cikin 50% ethanol da methanol.Yana yana da wani dangi hygroscopicity.Amma aikin saman dangi da ayyukan hemolytic suna da ƙarancin ƙarancin ƙarfi.Ba shi da haushi ga tsoka kuma shine madaidaicin kayan haɓaka mai ƙarfi da kayan haɓaka magunguna don allura.
Menene Hydroxypropyl beta-cyclodextrin da ake amfani dashi?
A fagen abinci da kayan yaji
Hydroxypropyl beta-cyclodextrin na iya inganta kwanciyar hankali da aikin dogon lokaci na ƙwayoyin sinadirai masu gina jiki, rufewa ko gyara mummunan wari da ɗanɗanon ƙwayoyin abinci mai gina jiki, da haɓaka tsarin samarwa da ingancin samfur.
A kayan shafawa
Za a iya amfani da albarkatun kayan shafawa a matsayin masu ƙarfafawa, emulsifiers, deodorizers, da dai sauransu, wanda zai iya rage yawan ƙarfafa kwayoyin halitta a cikin kayan shafawa a kan fata da mucous membrane kyallen takarda, haɓaka kwanciyar hankali na kayan aiki masu aiki, da hana haɓakawa da oxidation na abubuwan gina jiki. .Yana yana da wani dangi hygroscopicity.
A fannin likitanci
Hydroxypropyl beta-cyclodextrinna iya inganta narkewar ruwa na magungunan da ba a iya narkewa ba, haɓaka kwanciyar hankali na miyagun ƙwayoyi, inganta haɓakar ƙwayoyin cuta, haɓaka tasirin shirye-shiryen miyagun ƙwayoyi ko rage adadin, daidaitawa ko sarrafa saurin sakin magunguna, da rage yawan guba na miyagun ƙwayoyi.Ana iya amfani dashi azaman mai ɗaukar magunguna na baka, allurai, tsarin isar da magunguna na mucosal (ciki har da mucosa na hanci, dubura, cornea, da sauransu), tsarin isar da magunguna na transdermal, magungunan lipophilic, kuma ana iya amfani dashi azaman mai kare furotin stabilizer.
Lokacin aikawa: Oktoba-20-2023